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Answer to Case of the Week: Aug 13-Aug 20, 2008
5 different patients with same diagnosis

 


Clefts in the brain parenchyma that extend from the cortical surface to the ventricle (pia to ependyma) lined by dysplastic gray matter.
Diagnosis: SCHIZENCEPHALY

Frontal and parietal lobes near central sulcus is the most common location.

Closed lip lesions are small, with walls apposed to each other.

Open lip lesions can be very large mimicking hydranencephaly.

50% are bilateral.

Can be due to acquired insult or inherited mutation.

Intrauterine insults include CMV, maternal trauma or toxin exposure.

 

Differential Diagnosis:

Porencephaly-Lined by gliotic white matter

Hydranencephaly

Semi lobar Holoprosencephaly

Agenesis of corpus callosum with interhemispheric cyst

 

Dimple in wall of lateral ventricle-look for closed lip schizencephaly.

Angle of wall-PVL

Lump on wall-GM heterotopia or subependymal nodules of Tuberous sclerosis.

 

Residents Submitting Correct Diagnosis - Case of the Week
Radiology
Pediatrics
VCU Resident
  		• Maria Torrone
  		• Arash Chehrazi
  		• Kenny Uy
    Others
  		• Dishant ShahUnited States of America
  		• Roja TummaIndia
  		• Hani SharkeyUnited States of America
  		• Nagendar RaoIndia
  		• Yeshodha YennaIndia
  		• Gitanjali BajajIndia
  		• JAMAL ABAZIDSyrian Arab Republic
  		• Raghu MurthyIndia
  		• Joshua BallUnited States of America
    Disclaimer: This information is intended solely for resident review of presented cases which may or may not be pathologically proven. Information is derived from a number of published sources of varying reliability and does not represent original research from the institution. It is not intended to be comprehensive and should therefore not substitute for careful review of the literature.